Guides added after the initial list:

Tidal Waters Guide Service, LLC, Charlestown, SC – Light Tackle & Fly Fishing Charters, Captain Conner Bryant, 910-264-0917, tidalwatersguideservice.com

Chris Morris – Holston River Fishing Guides. Office: (828) 416-0159, Cell: (828) 773-3906; www.holstonriverflyfishing.com  chris@holstonriverflyfishing.com

Max & Macy Beck – Due South Outfitters, 2575 Hwy 105, Suite 60, Boone, NC 28607 828-355-9109; email: contact@duesouthoutfitters.com

 Capt Jerry Dilsaver provided this list of guides and links:

Capt. Tommy Rickman – Southport Angler Outfitters – fishsouthport.com – 910- 264-7722

Wilmington Area

Seth Vernon – Double Haul Guide Service – doublehaulguideservice.com – 910-233-4520
Capt. Allen Cain – Sightfish NC – sightfishnc.com – 336-613-2975
Capt. Jon Huff – Circle H Charters – circlehcharters.com – 910-617-2619
Capt. Lee Parsons – Gottafly Guide Service – 910-540-2464
Capt. Judson Brock – Muddy Fly Guide Service – muddyflyguideservice.com – 910-660-9631
Capt. Stu Caulder – Gold Leader Guide Service – facebook.com/goldleaderfishing –  910-264-2674

Topsail/Sneads Ferry/New River Area

Many of the Wilmington area guides also work this area.
Capt. Ethan Bilderback – Stellar Angler Guide Service – stellerangler.com – 443-758-3638
Capt. Allen Jernigan – Breadman Ventures – breadmanventures.com – 910- 467-1482  (Capt. Allen said he isn’t a fly fisher, but he can get knowledgeable fly fishermen on the fish to use their knowledge and skills)

Swansboro Area

Capt. John Mauser – Tailing Tide Guide Service – tailingtideguideservice.com– 910-340-4811
Pogie’s Fishing – Sales/rentals/multiple guides – pogiesfishing.com – 910-325-7876

Morehead City Area
Capt. Joe Shute – Capt. Joe Shute’s – captjoes.com – 252-240-2744
Capt. Tom Roller – WaterDog Guide Service – waterdogguideservice.com – 919-423-6310
Capt. Will Jones – Bounty Hunter Guide Service – bountyhunternc.com – 919-218-8451

New Bern/Oriental Area
Capt. Bobby Brewer – Baldheaded Bobby Guide Service – baldheadedbobby.com – 919-349-6112 (Capt. Bobby also does some trips to Tennessee and other places)
Capt. Gary Dubiel – Spec Fever Guide Service – specfever.com – 252-249-1520
Down East Guide Service – Multiple guides – downeastguideservice.com – 252-671-3474

Pamlico River/Sound Area and Roanoke Sound

Capt. Richard Andrews – Tar-Pam Guide Service – tarpamguide.com – 252-945-9715 (multiple guides)

Little River, S.C. Area

I did not find any guides in this area specializing in fly fishing.

Pawleys Island/Georgetown/Mclellanville, S.C. Area
Capt. Fred Rourk- Sweet Tea Charters – Facebook.com/sweetteacharters – 843-241-4767
Capt. Jordan Pate – Carolina Guide Service – carolinaguideservice.com – 843-814-7900
Capt. Jeff Lattig – Living Waters Guide Service – livingwaterguide.com – 843-997-4655
Captain Newman Weaver – Kingfisher Guide Service – gtownkingfisher.com – 843-318-0474

Charleston/Isle of Palms/Folly Beach, S.C. Area  (Some also fish farther south)
Capt. Mark Holyfield – Charleston Fly – charlestonfly.com – 843-790-3131
Capt. Peter Lawson-Johnson – Low Country Premiere Fly Fishing – lowcountrypremiereflyfishing.com – 203-249-4266
Capt. Harry Tomlinson – Charleston Fly Fishing Expeditions – chasflyfishing.com – 803-727-0697
Capt. Chris Wilson – Fin Addict Charters – charlestonflyfishingguide.com – 843-224-7462
Capt. John Irwin – Fly Right Charters – flyrightcharters.com – 843-860-4231
Capt. Ben Alderman – Ben Alderman Fishing – benalderman.com – 843-906-3630
Capt. Mark Phelps – Shore Thang Charters – shorethangcharters.com – 843-475-1274
Stores – Haddrell’s Point in Mt. Pleasant;  Charleston Angler in Downtown Charleston